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    The San Francisco 49ers (0-1) host a NFC West battle against the Seattle Seahawks (0-0) on Sunday, September 18, 2022 at Levi’s Stadium.

    The Seahawks are expected to lose by at least two scores (currently +10) versus the 49ers (with an over/under of 42.5 points).

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    Game Info, Betting Lines for San Francisco 49ers vs. Seattle Seahawks

    • Game Day: Sunday, September 18, 2022
    • Game Time: 4:05 PM ET
    • TV Channel: FOX
    • Location: Santa Clara, California
    • Stadium: Levi’s Stadium
    49ers vs Seahawks Betting Information
    Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
    49ers -10 -110 -110 42.5 -110 -110 -474 +358

    Betting Insights for 49ers

    • The 49ers compiled a 9-8-0 record against the spread last season.
    • The 49ers won their only game last season when playing as at least 10-point favorites.
    • 49ers games went over the point total eight out of 17 times last season.

    Stats & Insights for 49ers

    • The 49ers averaged 25.1 points per game last season, 3.6 more than the Seahawks gave up per outing (21.5).
    • When the 49ers put up more than 21.5 points last year, they were 8-3 against the spread and 9-2 overall.
    • Last season the Seahawks had a 7-5 record against the spread and a 5-7 record overall in games when they held opponents to less than 25.1 points.
    • The 49ers averaged just 3.4 fewer yards per game (375.7) than the Seahawks gave up per outing (379.1) last year.
    • In games that the 49ers picked up more than 379.1 yards last season, the team was 5-3 against the spread and 6-2 overall.
    • When the Seahawks held their opponents to fewer than 375.7 yards last year, they had a 7-3 record ATS and a 5-5 record overall.
    • The 49ers rushed for 127.4 yards per game last season, 13.8 more than the 113.6 the Seahawks allowed per contest.
    • Last season the 49ers had an 8-3 ATS record and a 9-2 overall record in games the team rushed for more than 113.6 yards.
    • Last season, the Seahawks were 8-5 against the spread and 6-7 overall when holding opponents to less than 127.4 yards on the ground.
    • The 49ers turned the ball over six more times (24 total) than the Seahawks forced a turnover (18) last year.

    49ers’ Best Players

    • Jimmy Garoppolo: 3,810 PASS YDS / 254 YPG / 68.3% / 20 TD / 12 INT
    • Elijah Mitchell: 207 CAR / 963 YDS / 87.5 YPG / 5 TD / 19 REC / 137 YDS / 12.5 YPG / 1 TD
    • Deebo Samuel: 59 CAR / 365 YDS / 22.8 YPG / 8 TD / 77 REC / 1,405 YDS / 87.8 YPG / 6 TD
    • George Kittle: 71 REC / 910 YDS / 65 YPG / 6 TD
    • Brandon Aiyuk: 56 REC / 826 YDS / 48.6 YPG / 5 TD
    • Nick Bosa: 52 TKL / 21 TFL / 15.5 SACK / 1 PD
    • Fred Warner: 137 TKL / 7 TFL / 0.5 SACK / 4 PD
    • Tashaun Gipson: 47 TKL / 1 TFL / 1 SACK / 2 INT / 3 PD

    Betting Insights for Seahawks

    • Against the spread, the Seahawks were 9-8-0 last season.
    • The Seahawks had six of its 17 games go over the point total last season.

    Stats & Insights for Seahawks

    • The Seahawks scored just 1.7 more points per game (23.2) than the 49ers surrendered (21.5) last season.
    • The Seahawks were 7-2 against the spread and 7-2 overall in games when they put up over 21.5 points last year.
    • Last season the 49ers had a 7-2 record against the spread and a 7-2 record overall in games when they held opponents to less than 23.2 points.
    • The Seahawks racked up 323.9 yards per game last year, just 13.9 more than the 310 the 49ers gave up per matchup.
    • When the Seahawks piled up more than 310 yards last year, the team was 5-4 against the spread and 5-4 overall.
    • When the 49ers kept their opponents to less than 323.9 yards last season, they had a 6-4 record ATS and a 6-4 record overall.
    • The Seahawks rushed for 122 yards per game last year, 18.5 more than the 103.5 the 49ers allowed per outing.
    • The Seahawks had a 7-2 ATS record and a 6-3 overall record when the team ran for more than 103.5 yards last year.
    • When the 49ers limited their opponents to less than 122 yards on the ground last year, they were 7-5 against the spread and 8-4 overall.
    • The Seahawks turned the ball over 13 times last year, seven fewer times than the 49ers forced turnovers (20).

    Best Players for Seahawks

    • Drew Lock: 787 PASS YDS / 131.2 YPG / 60.4% / 2 TD / 2 INT
    • Rashaad Penny: 119 CAR / 749 YDS / 74.9 YPG / 6 TD / 6 REC / 48 YDS / 4.8 YPG / 0 TD
    • Travis Homer: 21 CAR / 177 YDS / 12.6 YPG / 1 TD / 16 REC / 161 YDS / 11.5 YPG / 0 TD
    • Tyler Lockett: 73 REC / 1,175 YDS / 73.4 YPG / 8 TD
    • D.K. Metcalf: 75 REC / 967 YDS / 56.9 YPG / 12 TD
    • Noah Fant: 68 REC / 670 YDS / 41.9 YPG / 4 TD
    • Darrell Taylor: 32 TKL / 7 TFL / 6.5 SACK / 1 PD
    • Jordyn Brooks: 183 TKL / 10 TFL / 1 SACK / 5 PD
    • Quandre Diggs: 94 TKL / 1 TFL / 5 INT / 7 PD
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