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    The Arizona Cardinals (0-0) host the Kansas City Chiefs (0-0) at State Farm Stadium on Sunday, September 11, 2022.

    The Chiefs are the favorites (-3.5) in their matchup versus the Cardinals, with the over/under at 53.5 points. (In terms of the moneyline, the Chiefs are -187 and the Cardinals are +157.)

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    Game Info, Betting Lines for Kansas City Chiefs vs. Arizona Cardinals

    • Game Day: Sunday, September 11, 2022
    • Game Time: 4:25 PM ET
    • TV Channel: CBS
    • Location: Glendale, Arizona
    • Stadium: State Farm Stadium
    Chiefs vs Cardinals Betting Information
    Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
    Chiefs -3.5 -111 -109 53.5 -111 -109 -187 +157

    Betting Insights for Chiefs

    • The Chiefs put together an 8-9-0 ATS record last year.
    • The Chiefs covered the spread five times last season (5-8 ATS) when playing as at least 3.5-point favorites.
    • The Chiefs and their opponents combined to hit the over 10 out of 17 times last season.

    Stats & Insights for Chiefs

    • The Chiefs scored 28.2 points per game last season, 6.7 more than the Cardinals surrendered per outing (21.5).
    • The Chiefs were 7-5 against the spread and 9-3 overall in games when they put up over 21.5 points last year.
    • Last season the Cardinals had a 10-2 record against the spread and a 10-2 record overall in games when they held opponents to less than 28.2 points.
    • The Chiefs averaged 67.6 more yards per game (396.8) than the Cardinals gave up per outing (329.2) last year.
    • The Chiefs were 7-8 against the spread and 10-5 overall when the team picked up over 329.2 yards last season.
    • Last season the Chiefs racked up 115 rushing yards per game, just 0.2 more yards than the Cardinals allowed per contest (114.8).
    • Last season the Chiefs had a 4-4 ATS record and a 5-3 overall record in games the team rushed for over 114.8 yards.
    • Last season the Chiefs had 25 turnovers, two fewer than the Cardinals had takeaways (27).

    Chiefs’ Best Players

    • Patrick Mahomes II: 4,839 PASS YDS / 284.6 YPG / 66.3% / 37 TD / 13 INT / 66 CAR / 381 RUSH YDS / 2 TD
    • Clyde Edwards-Helaire: 119 CAR / 517 YDS / 30.4 YPG / 4 TD / 19 REC / 129 YDS / 7.6 YPG / 2 TD
    • Ronald Jones II: 101 CAR / 428 YDS / 25.2 YPG / 4 TD / 10 REC / 64 YDS / 3.8 YPG / 0 TD
    • Travis Kelce: 92 REC / 1,125 YDS / 66.2 YPG / 9 TD
    • Mecole Hardman: 59 REC / 693 YDS / 40.8 YPG / 2 TD
    • Marquez Valdes-Scantling: 26 REC / 430 YDS / 25.3 YPG / 3 TD
    • Chris Jones: 27 TKL / 8 TFL / 9 SACK / 5 PD
    • Nick Bolton: 112 TKL / 11 TFL / 3 PD
    • Deon Bush: 31 TKL / 2 INT / 5 PD

    Betting Insights for Cardinals

    • Against the spread, the Cardinals were 10-7-0 last year.
    • The Cardinals’ ATS record as underdogs of 3.5 points or more was 4-0 last season.
    • The Cardinals had eight of its 17 games go over the point total last year.

    Stats & Insights for Cardinals

    • Last year the Cardinals put up five more points per game (26.4) than the Chiefs gave up (21.4).
    • When the Cardinals put up over 21.4 points last year, they were 9-3 against the spread and 10-2 overall.
    • The Chiefs had a 6-3 record against the spread and a 9-0 record overall in games when they gave up fewer than 26.4 points last year.
    • The Cardinals racked up only 4.7 more yards per game (373.6) than the Chiefs gave up per contest (368.9) last year.
    • When the Cardinals totaled more than 368.9 yards last year, the team was 7-4 against the spread and 8-3 overall.
    • The Cardinals rushed for 122.1 yards per game last year, just 4.5 more yards than the 117.6 the Chiefs allowed per contest.
    • Last year the Cardinals had a 7-2 ATS record and a 7-2 overall record in games the team rushed for more than 117.6 yards.
    • The Cardinals had 15 giveaways last year, while the Chiefs had 29 takeaways.

    Best Players for Cardinals

    • Kyler Murray: 3,787 PASS YDS / 222.8 YPG / 69.2% / 24 TD / 10 INT / 88 CAR / 423 RUSH YDS / 5 TD
    • James Conner: 202 CAR / 752 YDS / 44.2 YPG / 15 TD / 37 REC / 375 YDS / 22.1 YPG / 3 TD
    • Darrel Williams: 144 CAR / 558 YDS / 32.8 YPG / 6 TD / 47 REC / 452 YDS / 26.6 YPG / 2 TD
    • Marquise Brown: 91 REC / 1,008 YDS / 59.3 YPG / 6 TD
    • A.J. Green: 54 REC / 848 YDS / 49.9 YPG / 3 TD
    • Zach Ertz: 74 REC / 763 YDS / 42.4 YPG / 5 TD
    • Markus Golden: 48 TKL / 10 TFL / 11 SACK / 1 PD
    • Jalen Thompson: 120 TKL / 3 TFL / 3 INT / 7 PD
    • Byron Murphy: 64 TKL / 0.5 SACK / 4 INT / 12 PD
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