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    Memorial Stadium is the venue where the Clemson Tigers (8-0) will battle the Louisville Cardinals (5-3) on Saturday, November 12, 2022.

    The Tigers are significant favorites (-7) in their matchup against the Cardinals, with the over/under being 52 points. (In terms of the moneyline, the Tigers are -276 and the Cardinals are +216.)

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    Game Info and Betting Lines for Clemson vs. Louisville

    • Game Day: Saturday, November 12, 2022
    • Game Time: 3:30 PM ET
    • TV Channel: ESPN
    • Location: Berkeley, California
    • Stadium: Memorial Stadium
    Tigers vs Cardinals Betting Information
    Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
    Tigers -7 -113 -109 52 -110 -110 -276 +216

    Clemson Betting Insights

    • Louisville is 6-3-0 against the spread this year.
    • Louisville games have hit the over in four out of nine opportunities (44.4%).

    Clemson Stats & Insights

    • Offensively, Clemson ranks 45th in the FBS with 422.5 yards per game. Meanwhile, its defense ranks 29th in total defense (333.6 yards allowed per contest).
    • Clemson has been a handful for opposing teams, as they rank top-25 in both scoring offense (20th-best with 37.1 points per game) and scoring defense (21st-best with 19.9 points allowed per game) this year.
    • Clemson is averaging 236.1 passing yards per game offensively this season (67th in the FBS), and is surrendering 244.3 passing yards per game (93rd) on the defensive side of the ball.
    • Defensively, Clemson has been a top-25 unit in terms of rushing yards, ranking eighth-best by allowing just 89.4 per game. The Tigers rank 40th on offense (186.4 rushing yards per game).
    • Clemson owns the 43rd-ranked defense this year in terms of third-down efficiency (35.9% third-down conversion rate allowed), and has been better on offense, ranking 15th-best with a 49.2% third-down percentage.
    • With 11 forced turnovers (81st in the FBS) against nine turnovers committed (23rd in the FBS), Clemson (+2) has the 53rd-ranked turnover margin in college football.

    Clemson’s Best Players

    • D.J. Uiagalelei has thrown for 1,993 yards, completing 64.8% of his passes and tossing 18 touchdowns and five interceptions this season. He’s also run for 382 yards (42.4 ypg) on 98 carries with four rushing touchdowns.
    • Will Shipley has carried the ball 135 times for a team-high 802 yards on the ground and has found the end zone 11 times. He’s also tacked on 24 catches for 170 yards (18.9 per game).
    • Antonio Williams’ 390 yards as a receiver pace the team. He’s been targeted 39 times and has totaled 33 catches and two touchdowns.
    • Joseph Ngata has put up a 346-yard season so far with two touchdowns, reeling in 24 passes on 42 targets.
    • Davis Allen has compiled 27 catches for 324 yards, an average of 36 yards per game. He’s scored three times as a receiver this season.
    • Myles Murphy has collected 5.5 sacks to lead the team, while also recording four TFL and 24 tackles.
    • Clemson’s top-tackler, Trenton Simpson, has 44 tackles and 0.5 sacks this year.
    • R.J. Mickens leads the team with two interceptions, while also recording 22 tackles, one TFL, and two passes defended.

    Louisville Betting Insights

    • Louisville’s ATS record is 6-3-0 this year.
    • Out of Louisville’s nine games with a set total, four have hit the over (44.4%).

    Louisville Stats & Insights

    • With 417.4 total yards per game on the offensive side of the ball, Louisville ranks 50th in the FBS in 2022. On defense, it ranks 51st, surrendering 362.8 total yards per contest.
    • Louisville’s defense has been leading the way for the team, as it ranks 23rd-best in the FBS with 20.6 points surrendered per game. In terms of offense, it is accumulating 29.8 points per game, which ranks 62nd.
    • Louisville is posting 220.4 passing yards per game on offense this season (86th-ranked). Meanwhile, it is giving up 229.3 passing yards per contest (65th-ranked) on defense.
    • Louisville is accumulating 197 rushing yards per game on offense this season (26th-ranked). Meanwhile, it is giving up 133.5 rushing yards per contest (49th-ranked) on defense.
    • From an offensive standpoint, Louisville is posting a 37% third-down conversion percentage (90th-ranked). It ranks 40th in the FBS on the other side of the ball (35.6% third-down rate allowed).
    • Louisville has generated 24 forced turnovers this season and have turned it over 13 times, resulting in a +11 turnover margin, which ranks fourth-best in the FBS.

    Louisville’s Best Players

    • Micale Cunningham has thrown for 1,471 yards on 123-of-199 passing with eight touchdowns and four interceptions this season. He has chipped on the ground, as well, with 541 yards and 11 rushing touchdowns.
    • Tiyon Evans has taken 74 carries and totaled 495 yards with five touchdowns.
    • Tyler Hudson paces his squad with 703 receiving yards on 46 receptions with one touchdown.
    • Ahmari Huggins-Bruce has 26 receptions (on 41 targets) for a total of 362 yards (40.2 yards per game) and two touchdowns this year.
    • Marshon Ford has racked up 309 reciving yards (34.3 ypg) and two touchdowns this season.
    • YaYa Diaby has collected 5.5 sacks to pace the team, while also picking up seven TFL and 22 tackles.
    • Louisville’s tackle leader, MoMo Sanogo, has 40 tackles, four TFL, and 2.5 sacks this year.
    • Yasir Abdullah has a team-leading two interceptions to go along with 27 tackles, six TFL, 4.5 sacks, and two passes defended.

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