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    The San Francisco 49ers (2-0) host the New York Giants (1-1) at Levi’s Stadium on Thursday, September 21, 2023.

    On defense, the 49ers were a top-five unit last season, ranking best by allowing only 16.3 points per game. They ranked sixth on offense (26.5 points per game). The Giants compiled 21.5 points per game on offense last season, which ranked them 15th in the NFL. On the other side of the ball, they ranked 17th, allowing 21.8 points per game.

    49ers vs. Giants Picks

    A majority of Splash Inc. users think the Giants will pull off an upset against the 49ers on Thursday, with 2.0% of users picking them to come out on top. Against the spread, 65.1% of users are picking the 49ers to cover the 10-point line.

    Game Info: 49ers vs. Giants

    • Game Day: Thursday, September 21, 2023
    • Game Time: 8:15 PM ET
    • TV Channel: Amazon Prime Video
    • Location: Santa Clara, California
    • Stadium: Levi’s Stadium

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    Before making a bet on Thursday’s San Francisco-New York spread (San Francisco -10) or total (44 points), see the betting trends and insights below.

    Game Trends for 49ers

    • The 49ers went 11-6-0 ATS last season.
    • The 49ers were favored by 10 points or more two times last season, and covered the spread in one of those games.
    • Last season, the combined scoring went over the point total nine times in 49ers games.

    Stats & Insights for 49ers

    • The 49ers put up 26.5 points per game last year, 4.7 more than the Giants surrendered per outing (21.8).
    • When the 49ers scored over 21.8 points last year, they were 9-3 against the spread and 11-1 overall.
    • When the Giants limited opponents to less than 26.5 points last year, they had a 11-1 record against the spread and a 9-2-1 record overall.
    • The 49ers averaged 365.6 yards per game last year, just 7.4 more than the 358.2 the Giants gave up per matchup.
    • The 49ers were 7-3 against the spread and 9-1 overall when the team amassed over 358.2 yards last year.
    • When the Giants held their opponents to fewer than 365.6 yards last year, they had a -2 record ATS and a – record overall.
    • The 49ers rushed for 138.8 yards per game last season, just 5.4 fewer yards than the 144.2 the Giants allowed per contest.
    • The 49ers had a 7-3 ATS record and a 9-1 overall record when the team ran for over 144.2 yards last year.
    • The Giants were -1 against the spread and – overall when holding opponents to less than 138.8 rushing yards last season.
    • The 49ers had 17 giveaways last year, while the Giants had 19 takeaways.

    Best Players for 49ers

    • Brock Purdy: 1,374 PASS YDS / 152.7 YPG / 67.1% / 13 TD / 4 INT
    • Christian McCaffrey: 244 CAR / 1,139 YDS / 67 YPG / 8 TD / 85 REC / 741 YDS / 43.6 YPG / 5 TD
    • Elijah Mitchell: 45 CAR / 279 YDS / 55.8 YPG / 2 TD / 3 REC / 7 YDS / 1.4 YPG / 0 TD
    • Brandon Aiyuk: 78 REC / 1,015 YDS / 59.7 YPG / 8 TD
    • George Kittle: 60 REC / 765 YDS / 51 YPG / 11 TD
    • Fred Warner: 130 TKL / 3 TFL / 2 SACK / 1 INT / 10 PD

    Game Trends for Giants

    • Against the spread, the Giants were 13-4-0 last year.
    • The Giants covered every time (2-0) as underdogs of 10 points or more last year.
    • Last season, seven of the Giants’ 17 games hit the over.

    Stats & Insights for Giants

    • The Giants averaged 5.2 more points per game (21.5) than the 49ers allowed (16.3) last season.
    • The Giants were 12-2 against the spread and 9-4-1 overall last season when the team notched more than 16.3 points.
    • When the 49ers gave up less than 21.5 points last year, they had a 11-3 record against the spread and a 12-2 record overall.
    • The Giants collected 33.3 more yards per game (333.9) than the 49ers gave up per contest (300.6) last season.
    • When the Giants churned out more than 300.6 yards last season, the team was 8-3 against the spread and 6-4-1 overall.
    • The 49ers had a -4 record ATS and a – record overall when holding their opponents to less than 333.9 yards last year.
    • The Giants rushed for 148.2 yards per game last season, 70.5 more than the 77.7 the 49ers allowed per outing.
    • When the Giants rushed for over 77.7 yards last season they compiled a 13-4 ATS record and a 9-7-1 overall record.
    • When the 49ers limited their opponents to fewer than 148.2 yards on the ground last season, they were -5 against the spread and – overall.
    • The Giants had 16 giveaways last year, while the 49ers had 30 takeaways.

    Best Players for Giants

    • Daniel Jones: 3,205 PASS YDS / 200.3 YPG / 67.2% / 15 TD / 5 INT / 120 CAR / 708 RUSH YDS / 7 TD
    • Saquon Barkley: 295 CAR / 1,312 YDS / 82 YPG / 10 TD / 57 REC / 338 YDS / 21.1 YPG / 0 TD
    • Darius Slayton: 46 REC / 724 YDS / 55.7 YPG / 2 TD
    • Parris Campbell: 63 REC / 623 YDS / 36.6 YPG / 3 TD
    • Isaiah Hodgins: 37 REC / 392 YDS / 43.6 YPG / 4 TD
    • Bobby Okereke: 149 TKL / 6 TFL / 5 PD
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