San Francisco 49ers vs. Denver Broncos Betting Lines & Preview | NFL Week 3

The San Francisco 49ers (1-1) visit the Denver Broncos (1-1) at Empower Field at Mile High on Sunday, September 25, 2022.

The 49ers are small favorites (-1) in their matchup against the Broncos, with the over/under at 46 points. (In terms of the moneyline, the 49ers are -118 and the Broncos are -102.)

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Game Info, Betting Lines for San Francisco 49ers vs. Denver Broncos

• Game Day: Sunday, September 25, 2022
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: Denver, Colorado
• Stadium: Empower Field at Mile High

Betting Insights for 49ers

• The 49ers is 1-1-0 against the spread this season.
• The 49ers are 1-1 against the spread when favored by 1 point or more this season.
• None of the 49ers’ two games with a set total this season have gone over the point total.

Stats & Insights for 49ers

• The 49ers have the 17th-ranked offense this year (352 yards per game), and they’ve been even more effective on the other side of the ball, ranking best with only 210 yards allowed per game.
• On the defensive side of the ball, the 49ers have been a top-five unit, ranking fourth-best by allowing only 13 points per game. They rank 21st on offense (18.5 points per game).
• The 49ers have struggled in the passing game, ranking fourth-worst in the NFL (169.5 passing yards per game) this season. However, they rank best defensively, giving up only 142.5 passing yards per game.
• The 49ers have been firing on all cylinders in the running game this season, as they rank fourth-best in rushing offense (182.5 rushing yards per game) and second-best in rushing defense (67.5 rushing yards allowed per game).
• The 49ers are averaging a 43.8% third-down percentage on offense, which ranks them 13th in the NFL. On the defensive side of the ball, they rank eighth, giving up a 33.3% third-down percentage.
• The 49ers have the best defense in the NFL in terms of yards per play allowed (4.4), while their offense is ranked 24th, gaining 5.2 per play.
• The 49ers have the fifth-best turnover margin in the league at +2, forcing four turnovers (fifth in NFL) while turning it over two times (12th in NFL).

49ers’ Best Players

• Jeff Wilson Jr.: 27 CAR / 106 YDS / 53 YPG / 0 TD / 4 REC / 27 YDS / 13.5 YPG / 0 TD
• Deebo Samuel: 12 CAR / 105 YDS / 52.5 YPG / 1 TD / 7 REC / 58 YDS / 29 YPG / 0 TD
• Brandon Aiyuk: 7 REC / 103 YDS / 51.5 YPG / 0 TD
• Jauan Jennings: 5 REC / 66 YDS / 33 YPG / 0 TD
• Nick Bosa: 9 TKL / 3 TFL / 3 SACK
• Talanoa Hufanga: 17 TKL / 3 TFL / 1 INT / 3 PD

Betting Insights for Broncos

• The Broncos have not covered the spread in a game yet this year (0-2-0).
• The Broncos have not hit the over on a point total in two games with a set over/under.

Stats & Insights for Broncos

• The Broncos have been thriving on defense, allowing only 243.5 total yards per contest (third-best). Offensively, they rank eighth by accumulating 391.5 total yards per game.
• The Broncos have been keeping opposing offenses in check on defense, giving up only 13 points per contest (fourth-best). On offense, they rank 26th by accumulating 16 points per game.
• The Broncos rank ninth in the NFL with 265.5 passing yards per game, but they’ve been carried by their defense, which ranks fifth-best by surrendering only 165.5 passing yards per contest.
• The Broncos’ run defense has been leading the way for the team, as they rank fifth-best in the NFL with 78 rushing yards conceded per game. In terms of offense, they are posting 126 rushing yards per game, which ranks 10th.
• In terms of third-down efficiency, the Broncos rank 15th in the NFL (40.7% third-down conversion rate) and eighth on defense (33.3% third-down rate allowed).
• In terms of yards per play, the Broncos rank ninth in the NFL (6.3) and sixth defensively (4.9 yards allowed per play).
• After forcing one turnover (22nd in NFL) and turning the ball over three times (19th in NFL) this season, the Broncos sport the 23rd-ranked turnover margin of -2.

Best Players for Broncos

• Russell Wilson: 559 PASS YDS / 279.5 YPG / 58.9% / 2 TD / 1 INT
• Javonte Williams: 22 CAR / 118 YDS / 59 YPG / 0 TD / 12 REC / 75 YDS / 37.5 YPG / 0 TD
• Melvin Gordon III: 22 CAR / 105 YDS / 52.5 YPG / 0 TD / 3 REC / 20 YDS / 10 YPG / 0 TD
• Courtland Sutton: 11 REC / 194 YDS / 97 YPG / 0 TD
• Jerry Jeudy: 5 REC / 113 YDS / 56.5 YPG / 1 TD
• Dre’Mont Jones: 7 TKL / 1 TFL / 2 SACK
• Alex Singleton: 14 TKL / 2 PD
• Russell Wilson: 0 TKL