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    The San Francisco 49ers (3-0) bring a three-game winning streak into a matchup with the Arizona Cardinals (1-2) on Sunday, October 1, 2023 at Levi’s Stadium.

    The 49ers have been making things happen on both sides of the ball this season, as they rank fourth-best in total offense (399 yards per game) and third-best in total defense (258.3 yards allowed per game). In terms of total yards, the Cardinals rank 18th in the NFL (329.7 total yards per game) and 26th on defense (367.7 total yards allowed per game).

    49ers vs. Cardinals Picks

    Currently, 1.5% of Splash Inc. users are picking the Cardinals to upset the 49ers, with 51.8% expecting the Cardinals to cover the 14-point spread on Sunday.

    Game Info: 49ers vs. Cardinals

    • Game Day: Sunday, October 1, 2023
    • Game Time: 4:25 PM ET
    • TV Channel: FOX
    • Location: Santa Clara, California
    • Stadium: Levi’s Stadium

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    Before you wager on Sunday’s San Francisco-Arizona spread (San Francisco -14) or over/under (44 points), see the betting trends and insights below.

    Game Trends for 49ers

    • The 49ers have covered the spread twice in three opportunities this season.
    • The 49ers have combined with their opponent to hit the over in one of three games with a set total (33.3%).

    Stats & Insights for 49ers

    • The 49ers have been clicking on all fronts this year, as they rank fourth-best in total offense (399 yards per game) and third-best in total defense (258.3 yards allowed per game).
    • The 49ers have been a handful for opposing teams, as they rank top-five in both scoring offense (third-best with 30 points per game) and scoring defense (fifth-best with 14 points allowed per game) this year.
    • On offense, the 49ers rank 10th in the NFL with 236.3 passing yards per game. Meanwhile, they rank 14th in passing yards allowed per contest (205.3).
    • The 49ers have been finding success on both offense and defense in the running game, ranking third-best in rushing offense (162.7 rushing yards per game) and third-best in rushing defense (53 rushing yards allowed per game).
    • The 49ers are averaging a 44.7% third-down conversion rate on offense, which ranks them 11th in the NFL. On defense, they rank 15th, surrendering a 36.6% third-down conversion rate.
    • The 49ers have been a tough opponent for opposing teams in terms of yards per play, as they rank top-five in both offensive yards per play (fourth-best with 6.2) and yards per play allowed on defense (second-best at 4.5) this season.
    • With five forced turnovers (seventh in NFL) against one turnover committed (first in NFL), the 49ers’ +4 turnover margin is the third-best in the NFL.

    Best Players for 49ers

    • Brock Purdy: 736 PASS YDS / 245.3 YPG / 67% / 4 TD / 0 INT
    • Christian McCaffrey: 60 CAR / 353 YDS / 117.7 YPG / 3 TD / 11 REC / 70 YDS / 23.3 YPG / 0 TD
    • Elijah Mitchell: 16 CAR / 52 YDS / 26 YPG / 0 TD
    • Deebo Samuel: 17 REC / 247 YDS / 82.3 YPG / 1 TD
    • Brandon Aiyuk: 11 REC / 172 YDS / 86 YPG / 2 TD
    • George Kittle: 13 REC / 139 YDS / 46.3 YPG / 0 TD
    • Deommodore Lenoir: 25 TKL / 1 INT / 1 PD

    Game Trends for Cardinals

    • The Cardinals are 3-0-0 against the spread this year.
    • The Cardinals have hit the over in two of three games with a set total (66.7%).

    Stats & Insights for Cardinals

    • The Cardinals rank 18th with 329.7 total yards per contest on offense, and they rank 26th with 367.7 total yards allowed per game on the defensive side of the ball.
    • In terms of points scored the Cardinals rank 12th in the NFL (24 points per game), and they are 16th on the other side of the ball (22.3 points allowed per contest).
    • With 173.3 passing yards per game on offense, the Cardinals rank 27th in the NFL. Defensively, they rank 21st, giving up 233 passing yards per game.
    • With 156.3 rushing yards per game on offense, the Cardinals rank sixth in the NFL. Defensively they rank 26th, giving up 134.7 rushing yards per game.
    • The Cardinals’ defense has been bottom-five on third down this season, surrendering a 50% third-down conversion percentage, which ranks fourth-worst in the NFL. On offense, they rank 18th with a 50% third-down rate.
    • The Cardinals’ offense has been paving the way for the team, as they rank fifth-best in the NFL with 6 yards per play. In terms of defense, they are allowing 5.7 yards per play, which ranks 21st.
    • With five forced turnovers (seventh in NFL) and two turnovers committed (sixth in NFL) this season, the Cardinals rank seventh in the NFL with a turnover margin of +3.

    Best Players for Cardinals

    • James Conner: 51 CAR / 266 YDS / 88.7 YPG / 2 TD / 7 REC / 26 YDS / 8.7 YPG / 0 TD
    • Joshua Dobbs: 12 CAR / 93 YDS / 31 YPG / 1 TD
    • Michael Wilson: 7 REC / 161 YDS / 53.7 YPG / 0 TD
    • Marquise Brown: 14 REC / 143 YDS / 47.7 YPG / 2 TD
    • Zach Ertz: 14 REC / 83 YDS / 27.7 YPG / 0 TD
    • Kyzir White: 30 TKL / 3 TFL / 1 SACK / 1 INT / 1 PD
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